{"id":2394,"date":"2026-05-22T07:00:02","date_gmt":"2026-05-22T07:00:02","guid":{"rendered":"https:\/\/www.thefullerene.com\/?p=2394"},"modified":"2026-05-22T07:05:25","modified_gmt":"2026-05-22T07:05:25","slug":"catalyst-poisoning-metal-free-fullerene-precursors","status":"publish","type":"post","link":"https:\/\/www.thefullerene.com\/ja\/catalyst-poisoning-metal-free-fullerene-precursors\/","title":{"rendered":"\u30d5\u30e9\u30fc\u30ec\u30f3\u304c\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u3092\u5236\u5fa1\u3057\u3001\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u304b\u3089\u9632\u5fa1\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\uff1a\u76ae\u819a\u5149\u9632\u5fa1\u306b\u95a2\u3059\u308b\u5206\u5b50\u89e3\u6790"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u76ae\u819a\u754c\u9762\u306f\u5e38\u306b\u592a\u967d\u7d2b\u5916\u7dda\uff08UVR\uff09\u306b\u66dd\u9732\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306fUVB\uff08290\u2013320 nm\uff09\u3068UVA\uff08320\u2013400 nm\uff09\u306e\u6ce2\u9577\u306b\u5206\u985e\u3055\u308c\u308b\u3002UVB\u304c\u4e3b\u306b\u8868\u76ae\u3092\u6a19\u7684\u3068\u3057\u3066\u76f4\u63a5\u7684\u306aDNA\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u4e00\u65b9\u3001UVA\u306f\u771f\u76ae\u6df1\u90e8\u307e\u3067\u6d78\u900f\u3057\u3001\u904e\u5270\u306a\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3092\u751f\u6210\u3059\u308b\u3002\u3053\u306e\u7d2b\u5916\u7dda\u8a98\u767a\u6027\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u65e9\u671f\u8001\u5316\uff08\u5149\u8001\u5316\uff09\u3084\u3001\u809d\u6591\u3001\u96c0\u6591\u3001\u65e5\u5149\u6027\u9ed2\u5b50\u3092\u542b\u3080\u8272\u7d20\u6c88\u7740\u904e\u5270\u75c7\u306b\u5bfe\u3059\u308b\u4e3b\u8981\u306a\u4e0a\u6d41\u30c8\u30ea\u30ac\u30fc\u3068\u306a\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u640d\u50b7\u306b\u5bfe\u6297\u3059\u308b\u305f\u3081\u3001\u73fe\u4ee3\u306e\u76ae\u819a\u79d1\u5b66\u7814\u7a76\u306f\u6975\u3081\u3066\u9ad8\u3044\u6297\u9178\u5316\u80fd\u3092\u6301\u3064\u30ca\u30ce\u6750\u6599\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304d\u305f\u3002\u305d\u306e\u4e2d\u3067\u3082\u3001\u30ab\u30fc\u30dc\u30f360\uff08<a href=\"https:\/\/www.thefullerene.com\/about-fullerene\/what-is-fullerene-c60\/\">C60<\/a>) \u30d5\u30e9\u30fc\u30ec\u30f3\u2014\u6b63\u4e8c\u5341\u9762\u4f53\u5bfe\u79f0\u6027\u3092\u6301\u3064\u4e2d\u7a7a\u306e\u7403\u72b6\u30b1\u30fc\u30b8\u69cb\u9020\u2014\u306f\u3001\u4e3b\u8981\u306a\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u300c\u30e9\u30b8\u30ab\u30eb\u30b9\u30dd\u30f3\u30b8\u300d\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u201c <a href=\"https:\/\/www.thefullerene.com\/about-fullerene\/what-is-fullerene-c60\/\">C60<\/a> \u89e6\u5a92\u52b9\u7387\u3067\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u4e2d\u548c\u3057\u3001\u5f93\u6765\u306e\u6297\u9178\u5316\u7269\u8cea\u306e\u6027\u80fd\u3092\u306f\u308b\u304b\u306b\u51cc\u99d5\u3059\u308b\u3002\u672c\u7a3f\u3067\u306f\u3001\u30d5\u30e9\u30fc\u30ec\u30f3\u304c\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u8abf\u7bc0\u3057\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u907a\u4f1d\u6bd2\u6027\u304b\u3089\u30d2\u30c8\u76ae\u819a\u3092\u4fdd\u8b77\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u5305\u62ec\u7684\u306b\u6982\u8aac\u3059\u308b\u3002.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u6b21<\/h2><nav><ul><li><a href=\"#1-the-melanogenesis-pathway-and-oxidative-triggers\">1. \u30e1\u30e9\u30cb\u30f3\u751f\u6210\u7d4c\u8def\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8a98\u56e0<\/a><\/li><li><a href=\"#undefined-1\">C60\u306b\u3088\u308b\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u306e\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u963b\u5bb3<\/a><ul><li><a href=\"#undefined-2\">\u4e0a\u6d41\u306eROS\u6d88\u53bb<\/a><\/li><li><a href=\"#undefined-3\">\u4e3b\u8981\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4f4e\u4e0b<\/a><\/li><\/ul><\/li><li><a href=\"#3-photoprotection-and-prevention-of-uv-induced-genotoxicity\">3. \u5149\u9632\u5fa1\u53ca\u3073\u7d2b\u5916\u7dda\u8a98\u767a\u907a\u4f1d\u6bd2\u6027\u306e\u4e88\u9632<\/a><ul><li><a href=\"#prevention-of-dna-damage-and-apoptosis\">DNA\u640d\u50b7\u304a\u3088\u3073\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u9632\u6b62<\/a><\/li><li><a href=\"#inhibition-of-lipid-peroxidation\">\u8102\u8cea\u904e\u9178\u5316\u306e\u963b\u5bb3<\/a><\/li><\/ul><\/li><li><a href=\"#4-cosmetic-synthesis-and-purity-standards\">4. \u5316\u7ca7\u54c1\u5408\u6210\u304a\u3088\u3073\u7d14\u5ea6\u57fa\u6e96<\/a><\/li><li><a href=\"#faq\">FAQ<\/a><ul><li><a href=\"#how-does-c60-fullerene-differ-from-vitamin-c-as-a-skin-brightening-active\">C60\u30d5\u30e9\u30fc\u30ec\u30f3\u306f\u3001\u808c\u306e\u660e\u308b\u3055\u3092\u5411\u4e0a\u3055\u305b\u308b\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3C\u3068\u3069\u306e\u3088\u3046\u306b\u7570\u306a\u308a\u307e\u3059\u304b\uff1f<\/a><\/li><li><a href=\"#can-fullerenes-be-formulated-in-both-water-based-and-oil-based-cosmetics\">\u30d5\u30e9\u30fc\u30ec\u30f3\u306f\u3001\u6c34\u6027\u304a\u3088\u3073\u6cb9\u6027\u306e\u4e21\u65b9\u306e\u5316\u7ca7\u54c1\u306b\u914d\u5408\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u304b\uff1f<\/a><\/li><li><a href=\"#does-c60-provide-actual-spf-protection-like-physical-sunscreens\">C60\u306f\u3001\u7269\u7406\u7684\u306a\u65e5\u713c\u3051\u6b62\u3081\u306e\u3088\u3046\u306b\u5b9f\u969b\u306eSPF\u9632\u5fa1\u3092\u63d0\u4f9b\u3057\u307e\u3059\u304b\uff1f<\/a><\/li><li><a href=\"#how-does-c60-prevent-uv-induced-dna-damage-in-skin-cells\">C60\u306f\u3001\u76ae\u819a\u7d30\u80de\u306b\u304a\u3044\u3066\u7d2b\u5916\u7dda\u8a98\u767a\u6027\u306eDNA\u640d\u50b7\u3092\u3069\u306e\u3088\u3046\u306b\u9632\u3050\u306e\u304b\u3002<\/a><\/li><li><a href=\"#are-there-any-side-effects-or-risks-associated-with-topical-c60\">\u5c40\u6240\u9069\u7528\u306eC60\u306b\u95a2\u9023\u3059\u308b\u526f\u4f5c\u7528\u3084\u30ea\u30b9\u30af\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/a><\/li><\/ul><\/li><li><a href=\"#references\">\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"1-the-melanogenesis-pathway-and-oxidative-triggers\" class=\"wp-block-heading\">1. \u30e1\u30e9\u30cb\u30f3\u751f\u6210\u7d4c\u8def\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u8a98\u56e0<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306f\u3001\u8868\u76ae\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306b\u5b58\u5728\u3059\u308b\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3068\u547c\u3070\u308c\u308b\u7279\u6b8a\u306a\u30ea\u30bd\u30bd\u30fc\u30e0\u69d8\u30aa\u30eb\u30ac\u30cd\u30e9\u5185\u3067\u8d77\u3053\u308b\u3001\u9ad8\u5ea6\u306b\u5236\u5fa1\u3055\u308c\u305f\u751f\u5316\u5b66\u7684\u7d4c\u8def\u3067\u3042\u308b\u3002\u3053\u306e\u7d4c\u8def\u306e\u57fa\u672c\u7684\u304b\u3064\u5f8b\u901f\u6bb5\u968e\u306f\u3001\u9285\u542b\u6709\u30e1\u30bf\u30ed\u9175\u7d20\u3067\u3042\u308b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\uff08EC 1.14.18.1\uff09\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u3002. <a href=\"https:\/\/en.wikipedia.org\/wiki\/Tyrosinase\" data-type=\"link\" data-id=\"https:\/\/en.wikipedia.org\/wiki\/Tyrosinase\" rel=\"nofollow noopener\" target=\"_blank\">\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc<\/a> \u306f\u30012\u3064\u306e\u9023\u7d9a\u3057\u305f\u7570\u306a\u308b\u53cd\u5fdc\u3092\u8abf\u6574\u3059\u308b\uff1a<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>L-\u30c1\u30ed\u30b7\u30f3\u3092L-3,4-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\uff08L-DOPA\uff09\u306b\u6c34\u9178\u5316\u3059\u308b\u30e2\u30ce\u30d5\u30a7\u30ce\u30e9\u30fc\u30bc\u30b5\u30a4\u30af\u30eb\u3002.<\/li>\n\n\n\n<li>L-DOPA\u3092\u9ad8\u53cd\u5fdc\u6027\u306eo-\u30c9\u30fc\u30d1\u30ad\u30ce\u30f3\u306b\u9178\u5316\u3059\u308b\u30b8\u30d5\u30a7\u30ce\u30e9\u30fc\u30bc\u30b5\u30a4\u30af\u30eb\u3002.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b9\u30eb\u30d5\u30d2\u30c9\u30ea\u30eb\u5316\u5408\u7269\uff08\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3084\u30b7\u30b9\u30c6\u30a4\u30f3\u306a\u3069\uff09\u304c\u5b58\u5728\u3057\u306a\u3044\u5834\u5408\u3001o-\u30c9\u30fc\u30d1\u30ad\u30ce\u30f3\u306f\u6025\u901f\u306b <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.2c00306\" data-type=\"link\" data-id=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.2c00306\" rel=\"nofollow noopener\" target=\"_blank\">\u975e\u9175\u7d20\u7684\u74b0\u5316<\/a> \u3092\u7d4c\u3066\u30c9\u30fc\u30d1\u30af\u30ed\u30e0\u3092\u5f62\u6210\u3059\u308b\u3002\u3053\u306e\u4e2d\u9593\u4f53\u306f\u305d\u306e\u5f8c\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea1\uff08TRP-1\uff09\u304a\u3088\u3073\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea2\uff08TRP-2\uff09\u306b\u3088\u3063\u3066\u89e6\u5a92\u3055\u308c\u3001\u4e0d\u6eb6\u6027\u306e\u8910\u9ed2\u8272\u8272\u7d20\u3067\u3042\u308b\u30e6\u30fc\u30e1\u30e9\u30cb\u30f3\u304c\u751f\u6210\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"686\" src=\"https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-1024x686.webp\" alt=\"\" class=\"wp-image-2400\" title=\"\" srcset=\"https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-1024x686.webp 1024w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-720x482.webp 720w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-300x201.webp 300w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-768x515.webp 768w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-1536x1029.webp 1536w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-18x12.webp 18w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html.webp 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">\u7570\u306a\u308b\u7a2e\u985e\u306e\u7d2b\u5916\u7dda\u304c\u7d30\u80de\u5185\u3078\u6d78\u900f\u3059\u308b\u6df1\u3055\u3001\u69d8\u3005\u306a\u76ae\u819a\u5c64\u306e\u5f62\u6210\u3001\u304a\u3088\u3073\u3053\u306e\u653e\u5c04\u7dda\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u7d30\u80de\u6a5f\u80fd\u306e\u4e3b\u306a\u5909\u5316<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3001TRP-1\u3001TRP-2\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u306f\u3001\u30de\u30b9\u30bf\u30fc\u5236\u5fa1\u56e0\u5b50\u3067\u3042\u308b\u30de\u30a4\u30af\u30ed\u30d5\u30bf\u30eb\u30df\u30a2\u95a2\u9023\u8ee2\u5199\u56e0\u5b50\uff08MITF\uff09\u306b\u3088\u3063\u3066\u8abf\u6574\u3055\u308c\u308b\u3002\u7d2b\u5916\u7dda\u66dd\u9732\u6642\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306f\u03b1-\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08\u03b1-MSH\uff09\u3092\u653e\u51fa\u3057\u3001\u3053\u308c\u304c\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u4e0a\u306e\u30e1\u30e9\u30ce\u30b3\u30eb\u30c1\u30f3-1\u53d7\u5bb9\u4f53\uff08MC1R\uff09\u306b\u7d50\u5408\u3057\u3001cAMP\/\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcA\uff08PKA\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066MITF\u3092\u4e0a\u65b9\u5236\u5fa1\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u6642\u306b\u3001\u7d2b\u5916\u7dda\u8a98\u767a\u6027ROS\u306f\u5f37\u529b\u306a\u30bb\u30ab\u30f3\u30c9\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306fp38\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08MAPK\uff09\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u3053\u308c\u304c\u76f4\u63a5\u7684\u306b <a href=\"https:\/\/medlineplus.gov\/download\/genetics\/gene\/mitf.pdf\" data-type=\"link\" data-id=\"https:\/\/medlineplus.gov\/download\/genetics\/gene\/mitf.pdf\" rel=\"nofollow noopener\" target=\"_blank\">MITF<\/a>, \u3092\u30ea\u30f3\u9178\u5316\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u767a\u73fe\u306e\u6025\u6fc0\u306a\u4e0a\u6607\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u76ee\u306b\u898b\u3048\u308b\u8272\u7d20\u6c88\u7740\u904e\u5270\u3092\u3082\u305f\u3089\u3059\u3002.<\/p>\n\n\n\n<h2 id=\"undefined-1\" class=\"wp-block-heading\">2. \u30d5\u30e9\u30fc\u30ec\u30f3\u306b\u3088\u308b\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u306e\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u963b\u5bb3 <a href=\"https:\/\/www.thefullerene.com\/about-fullerene\/what-is-fullerene-c60\/\">C60<\/a><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d5\u30e9\u30fc\u30ec\u30f3C60\u306f\u3001\u4e3b\u306b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u306e\u8ee2\u5199\u6a5f\u69cb\u3092\u5f15\u304d\u8d77\u3053\u3059\u524d\u306e\u4e0a\u6d41\u306e\u9178\u5316\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8272\u7d20\u6c88\u7740\u904e\u5270\u3092\u5236\u5fa1\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 id=\"undefined-2\" class=\"wp-block-heading\">\u4e0a\u6d41\u306eROS\u6d88\u53bb<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6c34\u6eb6\u6027\u3067\u30dd\u30ea\u30de\u30fc\u88ab\u8986\u3055\u308c\u305f\u8a98\u5c0e\u4f53\uff08\u4e00\u822c\u7684\u306b\u30dd\u30ea\u30d3\u30cb\u30eb\u30d4\u30ed\u30ea\u30c9\u30f3\uff08PVP\uff09\u3067\u5b89\u5b9a\u5316\u3055\u308c\u3001\u300c\u30e9\u30b8\u30ab\u30eb\u30b9\u30dd\u30f3\u30b8\u300d\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\uff09\u3068\u3057\u3066\u88fd\u5264\u5316\u3055\u308c\u305f\u5834\u5408\u3001C60\u306f <a href=\"https:\/\/starwars.fandom.com\/wiki\/Molecular_shielding\" rel=\"nofollow noopener\" target=\"_blank\">\u5206\u5b50\u30b7\u30fc\u30eb\u30c9<\/a>. \u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002UVA\u7167\u5c04\u6642\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u30d5\u30e9\u30fc\u30ec\u30f3\u306f\u6d3b\u6027\u7a2e\u3092\u8fc5\u901f\u306b\u5438\u53ce\u304a\u3088\u3073\u6d88\u5149\u3057\u3001\u9178\u5316\u30c8\u30ea\u30ac\u30fc\u3092\u9664\u53bb\u3059\u308b\u3002\u96fb\u6d41\u6e2c\u5b9a\u6cd5\u304a\u3088\u3073\u86cd\u5149\u6e2c\u5b9a\u6cd5\u306b\u3088\u308b\u30a2\u30c3\u30bb\u30a4\u306f\u3001\u3053\u306e\u6301\u7d9a\u7684\u306a\u30e9\u30b8\u30ab\u30eb\u6355\u6349\u304cp38 MAPK\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u6d3b\u6027\u5316\u3092\u505c\u6b62\u3055\u305b\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<h3 id=\"undefined-3\" class=\"wp-block-heading\">\u4e3b\u8981\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4f4e\u4e0b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">ROS\u5a92\u4ecb\u6027\u306eMITF\u6d3b\u6027\u5316\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001C60\u306f\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u30de\u30eb\u30c1\u9175\u7d20\u8907\u5408\u4f53\u5168\u4f53\u306e\u4e0b\u6d41\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3002\u7814\u7a76\u306b\u3088\u308a\u3001C60\u306b\u3088\u308b\u51e6\u7406\u306f\u4ee5\u4e0b\u3092\u6709\u610f\u306b\u4e0b\u65b9\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MITF<\/strong> \u907a\u4f1d\u5b50\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3002.<\/li>\n\n\n\n<li><strong>\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc<\/strong> \u9175\u7d20\u6d3b\u6027\u304a\u3088\u3073\u7dcf\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u3002.<\/li>\n\n\n\n<li><strong>TRP-1\u304a\u3088\u3073TRP-2<\/strong> \u306e\u8ee2\u5199\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u6210\u719f\u306e\u9632\u6b62\u3002.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001\u30d5\u30e9\u30fc\u30ec\u30f3\u306fUVB\u66dd\u9732\u5f8c\u306e\u518d\u69cb\u7bc9\u30d2\u30c8\u8868\u76ae\uff08RhE\uff09\u306b\u304a\u3051\u308b\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3E2\uff08PGE2\uff09\u306e\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3002PGE2\u306f <a href=\"https:\/\/en.wikipedia.org\/wiki\/Paracrine_signaling\" rel=\"nofollow noopener\" target=\"_blank\">\u30d1\u30e9\u30af\u30ea\u30f3\u523a\u6fc0\u56e0\u5b50<\/a> \u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u6a39\u72b6\u7a81\u8d77\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\uff08\u6210\u719f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u3092\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306b\u79fb\u884c\u3055\u305b\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3059\u308b\uff09\u305f\u3081\u3001C60\u306b\u3088\u308b\u305d\u306e\u4e0b\u65b9\u5236\u5fa1\u306f\u3001\u76ae\u819a\u306e\u65e5\u713c\u3051\u3084\u30b7\u30df\u5f62\u6210\u3092\u9632\u3050\u305f\u3081\u306e\u5f37\u529b\u306a\u4e8c\u6b21\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002.<\/p>\n\n\n\n<h2 id=\"3-photoprotection-and-prevention-of-uv-induced-genotoxicity\" class=\"wp-block-heading\">3. \u5149\u9632\u5fa1\u53ca\u3073\u7d2b\u5916\u7dda\u8a98\u767a\u907a\u4f1d\u6bd2\u6027\u306e\u4e88\u9632<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f93\u6765\u306e\u7f8e\u767d\u6709\u52b9\u6210\u5206\u304c\u9175\u7d20\u7d4c\u8def\u306e\u307f\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001C60\u306f\u8868\u76ae\u7d30\u80de\u3092\u7269\u7406\u7684\u306a\u7d2b\u5916\u7dda\u969c\u5bb3\u3084\u907a\u4f1d\u6bd2\u6027\u304b\u3089\u4fdd\u8b77\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5e83\u57df\u30b9\u30da\u30af\u30c8\u30eb\u306e\u9632\u5fa1\u3092\u63d0\u4f9b\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 id=\"prevention-of-dna-damage-and-apoptosis\" class=\"wp-block-heading\">DNA\u640d\u50b7\u304a\u3088\u3073\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u9632\u6b62<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8d85\u9ad8\u6c34\u9178\u5316\u30d5\u30e9\u30fc\u30ec\u30f3\u8a98\u5c0e\u4f53\u3001\u3059\u306a\u308f\u3061 <a href=\"https:\/\/www.researchgate.net\/publication\/47366690_Fullerenol_A_new_nanopharmaceutic\" rel=\"nofollow noopener\" target=\"_blank\">\u30d5\u30e9\u30fc\u30ec\u30ce\u30fc\u30eb<\/a> \uff08\u4f8b\uff1aC60(OH)44\uff09\u306f\u3001\u5353\u8d8a\u3057\u305f\u6c34\u6eb6\u6027\u3068\u751f\u4f53\u9069\u5408\u6027\u3092\u6709\u3059\u308b\u3002\u30d2\u30c8\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\uff08HaCaT\uff09\u306b\u304a\u3044\u3066\u3001\u30d5\u30e9\u30fc\u30ec\u30ce\u30fc\u30eb\u306b\u3088\u308b\u524d\u51e6\u7406\u306f\u3001UVB\u5149\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u6709\u610f\u306b\u6291\u5236\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306f\u3001\u30d5\u30e9\u30fc\u30ec\u30ce\u30fc\u30eb\u306f\u7d30\u80de\u6838\u3092\u653b\u6483\u3059\u308b\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\uff08\u2022OH\uff09\u3092\u4e2d\u548c\u3057\u3001\u30af\u30ed\u30de\u30c1\u30f3\u51dd\u7e2e\u3092\u5927\u5e45\u306b\u4f4e\u6e1b\u3057\u3001\u76ae\u819a\u767a\u764c\u306e\u539f\u56e0\u3068\u306a\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u5909\u7570\u3067\u3042\u308b\u30b7\u30af\u30ed\u30d6\u30bf\u30f3\u30d4\u30ea\u30df\u30b8\u30f3\u4e8c\u91cf\u4f53\uff08CPD\uff09\u306e\u5f62\u6210\u3092\u6291\u5236\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 id=\"inhibition-of-lipid-peroxidation\" class=\"wp-block-heading\">\u8102\u8cea\u904e\u9178\u5316\u306e\u963b\u5bb3<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u8102\u3001\u7279\u306b <a href=\"https:\/\/en.wikipedia.org\/wiki\/Squalene\" rel=\"nofollow noopener\" target=\"_blank\">\u30b9\u30af\u30a2\u30ec\u30f3<\/a>, \u306f\u3001UVB\u8a98\u767a\u6027\u306e\u904e\u9178\u5316\u306b\u5bfe\u3057\u3066\u975e\u5e38\u306b\u8106\u5f31\u3067\u3042\u308a\u3001\u76ae\u819a\u30d0\u30ea\u30a2\u3092\u640d\u50b7\u3057\u5c0b\u5e38\u6027\u3056\u7621\u3092\u60aa\u5316\u3055\u305b\u308b\u708e\u75c7\u6027\u526f\u7523\u7269\u3092\u751f\u6210\u3059\u308b\u3002\u89aa\u6cb9\u6027C60\u306f\u3001\u690d\u7269\u7531\u6765\u30b9\u30af\u30a2\u30e9\u30f3\uff08\u4f8b\uff1aLipoFullerene\uff09\u306b\u53ef\u6eb6\u5316\u3055\u308c\u308b\u3068\u3001\u89d2\u8cea\u5c64\u3084\u76ae\u8102\u817a\u306e\u8102\u8cea\u4e8c\u91cd\u5c64\u306b\u5bb9\u6613\u306b\u7d44\u307f\u8fbc\u307e\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">UVB\u7167\u5c04\u4e0b\u3067\u3001\u89aa\u6cb9\u6027C60\u306f\u30b9\u30af\u30a2\u30ec\u30f3\u306e\u9178\u5316\u7684\u5206\u89e3\u3092\u9632\u304e\u3001\u819c\u306e\u6d41\u52d5\u6027\u3092\u7dad\u6301\u3057\u3001\u76ae\u819a\u7d05\u6591\u3092\u4f4e\u6e1b\u3057\u3001\u81ea\u7136\u306a\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u640d\u306a\u3046\u3053\u3068\u306a\u304f\u708e\u75c7\u6027\u3056\u7621\u75c5\u5909\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3002.<\/p>\n\n\n\n<h2 id=\"4-cosmetic-synthesis-and-purity-standards\" class=\"wp-block-heading\">4. \u5316\u7ca7\u54c1\u5408\u6210\u304a\u3088\u3073\u7d14\u5ea6\u57fa\u6e96<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5148\u9032\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u5264\u306b\u304a\u3051\u308bC60\u306e\u6709\u52b9\u6027\u306f\u3001\u5206\u5b50\u306e\u7d14\u5ea6\u306b\u53b3\u5bc6\u306b\u4f9d\u5b58\u3059\u308b\u3002\u5f93\u6765\u306e <a href=\"https:\/\/www.thefullerene.com\/what-is-the-arc-discharge-method\/\" data-type=\"link\" data-id=\"https:\/\/www.thefullerene.com\/what-is-the-arc-discharge-method\/\">\u30ab\u30fc\u30dc\u30f3\u30a2\u30fc\u30af\u653e\u96fb<\/a> \u306b\u3088\u308b\u30d5\u30e9\u30fc\u30ec\u30f3\u5408\u6210\u3067\u306f\u3001\u62bd\u51fa\u3068\u5206\u96e2\u306b\u30c8\u30eb\u30a8\u30f3\u306a\u3069\u306e\u6709\u6a5f\u6eb6\u5a92\u304c\u3057\u3070\u3057\u3070\u4f7f\u7528\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u82b3\u9999\u65cf\u70ad\u5316\u6c34\u7d20\u306e\u5fae\u91cf\u304c\u4e2d\u7a7a\u306e\u70ad\u7d20\u30b1\u30fc\u30b8\u5185\u306b\u9589\u3058\u8fbc\u3081\u3089\u308c\u305f\u307e\u307e\u306b\u306a\u308b\u3068\u3001\u91cd\u5ea6\u306e\u7d30\u80de\u6bd2\u6027\u3092\u8a98\u767a\u3057\u3001\u751f\u7269\u5b66\u7684\u5229\u70b9\u3092\u76f8\u6bba\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306e\u5b89\u5168\u6027\u306e\u61f8\u5ff5\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u3001\u9ad8\u7d1a\u30b9\u30ad\u30f3\u30b1\u30a2\u539f\u6599\u306f\u53b3\u683c\u306a\u533b\u85ac\u54c1\u57fa\u6e96\u306e\u4e0b\u3067\u88fd\u9020\u3055\u308c\u3066\u3044\u308b\u3002\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u5148\u99c6\u8005\u3067\u3042\u308bHealthyking\u3068\u63d0\u643a\u3059\u308b\u696d\u754c\u30ea\u30fc\u30c0\u30fc\u3067\u3042\u308bCarbonsphere\u306a\u3069\u306e\u4f01\u696d\u306f\u3001\u9ad8\u5ea6\u306a <a href=\"https:\/\/www.thefullerene.com\/what-is-continuous-combustion-fullerene\/\">\u9023\u7d9a\u71c3\u713c\u6280\u8853<\/a>. \u3092\u5229\u7528\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u74b0\u5883\u306b\u512a\u3057\u304f\u7121\u6eb6\u5a92\u306e\u7cbe\u88fd\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u3059\u3079\u3066\u306e\u63ee\u767a\u6027\u6709\u6a5f\u5316\u5408\u7269\u3092\u9664\u53bb\u3057\u3001\u9577\u671f\u7684\u306a\u5c40\u6240\u4f7f\u7528\u306b\u5bfe\u3057\u3066\u5b8c\u5168\u306b\u7121\u6bd2\u3067\u975e\u523a\u6fc0\u6027\u3067\u3042\u308b\u3053\u3068\u304c\u751f\u7269\u5b66\u7684\u306b\u691c\u8a3c\u3055\u308c\u305f\u3001\u8d85\u9ad8\u7d14\u5ea6\uff0899.95%\uff09\u306e\u5316\u7ca7\u54c1\u30b0\u30ec\u30fc\u30c9C60\u6210\u5206\u3092\u751f\u307f\u51fa\u3059\u3002.<\/p>\n\n\n\n<h2 id=\"faq\" class=\"wp-block-heading\">FAQ<\/h2>\n\n\n\n<h3 id=\"how-does-c60-fullerene-differ-from-vitamin-c-as-a-skin-brightening-active\" class=\"wp-block-heading\">C60\u30d5\u30e9\u30fc\u30ec\u30f3\u306f\u3001\u808c\u306e\u660e\u308b\u3055\u3092\u5411\u4e0a\u3055\u305b\u308b\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3C\u3068\u3069\u306e\u3088\u3046\u306b\u7570\u306a\u308a\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d3\u30bf\u30df\u30f3C\uff08L-\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u306f\u72a0\u7272\u7684\u9084\u5143\u5264\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u4e2d\u548c\u3059\u308b\u904e\u7a0b\u3067\u6d88\u8cbb\u3055\u308c\u9178\u5316\u3055\u308c\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002.<sup><\/sup> \u307e\u305f\u3001\u5149\u3001\u7a7a\u6c17\u3001\u71b1\u306b\u3055\u3089\u3055\u308c\u308b\u3068\u975e\u5e38\u306b\u4e0d\u5b89\u5b9a\u3067\u5206\u89e3\u3059\u308b\u3002\u5bfe\u7167\u7684\u306b\u3001C60\u306f\u975e\u5e38\u306b\u5b89\u5b9a\u3057\u305f\u300c\u30e9\u30b8\u30ab\u30eb\u30b9\u30dd\u30f3\u30b8\u300d\u3067\u3042\u308a\u3001\u5206\u89e3\u3059\u308b\u3053\u3068\u306a\u304f\u8907\u6570\u306eROS\u5206\u5b50\u3092\u89e6\u5a92\u7684\u306b\u4e2d\u548c\u3057\u3001\u76ae\u819a\u5185\u306724\u6642\u9593\u4ee5\u4e0a\u306b\u308f\u305f\u308a\u305d\u306e\u5149\u5b89\u5b9a\u6027\u3068\u52b9\u529b\u3092\u7dad\u6301\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 id=\"can-fullerenes-be-formulated-in-both-water-based-and-oil-based-cosmetics\" class=\"wp-block-heading\">\u30d5\u30e9\u30fc\u30ec\u30f3\u306f\u3001\u6c34\u6027\u304a\u3088\u3073\u6cb9\u6027\u306e\u4e21\u65b9\u306e\u5316\u7ca7\u54c1\u306b\u914d\u5408\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u304b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u306f\u3044\u3002\u7d14\u7c8b\u306aC60\u306f\u5929\u7136\u306b\u758e\u6c34\u6027\u3067\u3042\u308a\u3001\u76ae\u8102\u306e\u8c4a\u5bcc\u306a\u69cb\u9020\u3092\u6a19\u7684\u3068\u3057\u7d30\u80de\u819c\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u3001\u6cb9\u6027\u88fd\u5264\uff08\u4f8b\uff1a\u690d\u7269\u7531\u6765\u30b9\u30af\u30a2\u30e9\u30f3\u4e2d\uff09\u306b\u7406\u60f3\u7684\u3067\u3059\u3002\u30bb\u30e9\u30e0\u3084\u5316\u7ca7\u6c34\u306a\u3069\u306e\u6c34\u6027\u7528\u9014\u306b\u306f\u3001\u88fd\u5264\u8a2d\u8a08\u8005\u306f\u30dd\u30ea\u30de\u30fc\u88ab\u8986\u8907\u5408\u4f53\uff08PVP\u88ab\u8986C60\u306a\u3069\uff09\u307e\u305f\u306f\u9ad8\u6c34\u9178\u5316\u3055\u308c\u305f\u6c34\u6eb6\u6027\u30d5\u30e9\u30fc\u30ec\u30ce\u30fc\u30eb\uff08C60(OH)x\uff09\u3092\u5229\u7528\u3057\u3001\u3053\u308c\u3089\u306f\u6c34\u76f8\u306b\u5bb9\u6613\u306b\u5206\u6563\u3057\u307e\u3059\u3002.<\/p>\n\n\n\n<h3 id=\"does-c60-provide-actual-spf-protection-like-physical-sunscreens\" class=\"wp-block-heading\">C60\u306f\u3001\u7269\u7406\u7684\u306a\u65e5\u713c\u3051\u6b62\u3081\u306e\u3088\u3046\u306b\u5b9f\u969b\u306eSPF\u9632\u5fa1\u3092\u63d0\u4f9b\u3057\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u3044\u3044\u3048\u3001C60\u306f\u9178\u5316\u4e9c\u925b\u3084\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u3088\u3046\u306a\u7121\u6a5f\u7d2b\u5916\u7dda\u30d5\u30a3\u30eb\u30bf\u30fc\u3092\u4ee3\u66ff\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002C60\u306b\u306f\u5149\u6563\u4e71\u6027\u3084\u3044\u304f\u3064\u304b\u306e\u7d2b\u5916\u7dda\u5438\u53ce\u7279\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u4e3b\u306a\u5f79\u5272\u306f\u751f\u7269\u5b66\u7684\u5149\u9632\u5fa1\u3067\u3059\u3002\u3053\u308c\u306f\u4e8c\u6b21\u9632\u5fa1\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u4e00\u6b21\u65e5\u713c\u3051\u6b62\u3081\u3092\u3059\u308a\u629c\u3051\u305f\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u5927\u91cf\u306e\u6d3b\u6027\u9178\u7d20\u7a2e\u3092\u4e2d\u548c\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u7d30\u80de\u58ca\u6b7b\u3084DNA\u640d\u50b7\u3092\u9632\u304e\u307e\u3059\u3002.<\/p>\n\n\n\n<h3 id=\"how-does-c60-prevent-uv-induced-dna-damage-in-skin-cells\" class=\"wp-block-heading\">C60\u306f\u3001\u76ae\u819a\u7d30\u80de\u306b\u304a\u3044\u3066\u7d2b\u5916\u7dda\u8a98\u767a\u6027\u306eDNA\u640d\u50b7\u3092\u3069\u306e\u3088\u3046\u306b\u9632\u3050\u306e\u304b\u3002<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">UVA\u304a\u3088\u3073UVB\u66dd\u9732\u306f\u3001DNA\u9396\u3092\u653b\u6483\u3059\u308b\u7d30\u80de\u5185\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u3068\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u30d5\u30e9\u30fc\u30ec\u30f3\u306f\u8fc5\u901f\u306b\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306b\u4fb5\u5165\u3057\u3001\u3053\u308c\u3089\u306e\u5c40\u5728\u5316\u3057\u305f\u30e9\u30b8\u30ab\u30eb\u3092\u6355\u6349\u3057\u3001\u30af\u30ed\u30de\u30c1\u30f3\u51dd\u7e2e\u3068\u3001\u76ae\u819a\u764c\u306e\u4e3b\u306a\u524d\u99c6\u4f53\u3067\u3042\u308b\u30b7\u30af\u30ed\u30d6\u30bf\u30f3\u30d4\u30ea\u30df\u30b8\u30f3\u4e8c\u91cf\u4f53\uff08CPD\uff09\u306e\u5f62\u6210\u3092\u6709\u610f\u306b\u6291\u5236\u3057\u307e\u3059\u3002.<\/p>\n\n\n\n<h3 id=\"are-there-any-side-effects-or-risks-associated-with-topical-c60\" class=\"wp-block-heading\">\u5c40\u6240\u9069\u7528\u306eC60\u306b\u95a2\u9023\u3059\u308b\u526f\u4f5c\u7528\u3084\u30ea\u30b9\u30af\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In vivo\u304a\u3088\u3073in vitro\u306e\u76ae\u819a\u79d1\u5b66\u7684\u5b89\u5168\u6027\u8a66\u9a13\u306f\u3001\u9ad8\u7d14\u5ea6\u306e\u5316\u7ca7\u54c1\u30b0\u30ec\u30fc\u30c9C60\uff08Carbonsphere\u304a\u3088\u3073Healthyking\u306b\u3088\u3063\u3066\u88fd\u9020\u3055\u308c\u308b\u6607\u83ef\u30fb\u7121\u6eb6\u5a92\u30b0\u30ec\u30fc\u30c9\u306a\u3069\uff09\u304c\u3001\u76ae\u819a\u523a\u6fc0\u3001\u611f\u4f5c\u3001\u307e\u305f\u306f\u907a\u4f1d\u6bd2\u6027\u3092\u5f15\u304d\u8d77\u3053\u3055\u306a\u3044\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u307e\u3059\u3002\u4e3b\u306a\u30ea\u30b9\u30af\u306f\u3001\u6b8b\u7559\u30c8\u30eb\u30a8\u30f3\u6eb6\u5a92\u3092\u542b\u3080\u53ef\u80fd\u6027\u306e\u3042\u308b\u4f4e\u30b0\u30ec\u30fc\u30c9\u306e\u5de5\u696d\u7528C60\u306b\u5b58\u5728\u3057\u307e\u3059\u3002.<sup><\/sup><\/p>\n\n\n\n<h2 id=\"references\" class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Xiao, L., Matsubayashi, K., &amp; Miwa, N. (2007). <em>Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues.<\/em> Archives of Dermatological Research, 299(5-6), 245-257. <a href=\"https:\/\/doi.org\/10.1007\/s00403-007-0740-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1007\/s00403-007-0740-2<\/a> \u201c<\/li>\n\n\n\n<li>Saitoh, Y., Miyanishi, A., Mizuno, H., Kato, S., Aoshima, H., Kokubo, K., &amp; Miwa, N. (2011). <em>Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages.<\/em> Journal of Photochemistry and Photobiology B: Biology, 102(1), 69-76. <a href=\"https:\/\/doi.org\/10.1016\/j.jphotobiol.2010.09.006\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1016\/j.jphotobiol.2010.09.006<\/a> \u201c<\/li>\n\n\n\n<li>Aoshima, H., Yamana, S., Nakamura, S., &amp; Mashino, T. (2010). <em>Evaluation of the safety of water-soluble polymer-enwrapped fullerenes as antioxidants in cosmetic and pharmaceutical preparations.<\/em> Journal of Toxicological Sciences, 35(3), 401-409. <a href=\"https:\/\/doi.org\/10.2131\/jts.35.401\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.2131\/jts.35.401<\/a> \u201c<\/li>\n\n\n\n<li>Inui, S., Aoshima, H., Nishimori, A., &amp; Itami, S. (2011). <em>Improvement of acne vulgaris by topical fullerene.<\/em> Journal of Dermatology, 38(11), 1072-1077. <a href=\"https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01257.x\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01257.x<\/a> \u201c<\/li>\n\n\n\n<li>Standardized Guidelines on the Safety Assessment of Fullerenes in Cosmetics. (2023). Scientific Committee on Consumer Safety (SCCS), European Commission. <a href=\"https:\/\/doi.org\/10.2772\/12171328\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.2772\/12171328<\/a> \u201c<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>The cutaneous interface is constantly exposed to solar ultraviolet radiation (UVR), which is divided into UVB (290\u2013320 nm) and UVA (320\u2013400 nm) wavelengths. While UVB primarily targets the epidermis to cause direct DNA lesions, UVA penetrates deep into the dermis, generating an excess of reactive oxygen species (ROS). This UV-induced oxidative stress represents the primary upstream trigger for premature senescence (photoaging) and hyperpigmentation disorders, including melasma, ephelides (freckles), and solar lentigines. To counteract this damage, modern dermatological research has focused on nanomaterials with extreme antioxidant capacities. Among these, Carbon 60 (C60) fullerene\u2014a hollow, spherical cage of icosahedral symmetry\u2014has emerged as a premier active ingredient. Acting as a &#8220;radical sponge,&#8221; C60 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2400,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_gspb_post_css":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-2394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"blocksy_meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/posts\/2394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/comments?post=2394"}],"version-history":[{"count":0,"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/posts\/2394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/media\/2400"}],"wp:attachment":[{"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/media?parent=2394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/categories?post=2394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thefullerene.com\/ja\/wp-json\/wp\/v2\/tags?post=2394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}