{"id":2394,"date":"2026-05-22T07:00:02","date_gmt":"2026-05-22T07:00:02","guid":{"rendered":"https:\/\/www.thefullerene.com\/?p=2394"},"modified":"2026-05-22T07:05:25","modified_gmt":"2026-05-22T07:05:25","slug":"catalyst-poisoning-metal-free-fullerene-precursors","status":"publish","type":"post","link":"https:\/\/www.thefullerene.com\/zh\/catalyst-poisoning-metal-free-fullerene-precursors\/","title":{"rendered":"\u5bcc\u52d2\u70ef\u5982\u4f55\u8c03\u63a7\u9ed1\u8272\u7d20\u5408\u6210\u5e76\u62b5\u5fa1\u7d2b\u5916\u7ebf\u635f\u4f24\uff1a\u76ae\u80a4\u5149\u4fdd\u62a4\u7684\u5206\u5b50\u673a\u5236\u5206\u6790"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u76ae\u80a4\u754c\u9762\u6301\u7eed\u66b4\u9732\u4e8e\u592a\u9633\u7d2b\u5916\u7ebf\u8f90\u5c04\uff08UVR\uff09\u4e4b\u4e0b\uff0c\u7d2b\u5916\u7ebf\u8f90\u5c04\u5206\u4e3aUVB\uff08290\u2013320 nm\uff09\u548cUVA\uff08320\u2013400 nm\uff09\u6ce2\u6bb5\u3002UVB\u4e3b\u8981\u4f5c\u7528\u4e8e\u8868\u76ae\uff0c\u5bfc\u81f4\u76f4\u63a5\u7684DNA\u635f\u4f24\uff0c\u800cUVA\u5219\u6df1\u5165\u771f\u76ae\u5c42\uff0c\u4ea7\u751f\u8fc7\u91cf\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u3002\u8fd9\u79cd\u7531\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u6c27\u5316\u5e94\u6fc0\u662f\u5bfc\u81f4\u76ae\u80a4\u8fc7\u65e9\u8870\u8001\uff08\u5149\u8001\u5316\uff09\u53ca\u8272\u7d20\u6c89\u7740\u7d0a\u4e71\uff08\u5305\u62ec\u9ec4\u8910\u6591\u3001\u96c0\u6591\u548c\u65e5\u5149\u6027\u96c0\u6591\u6837\u75e3\uff09\u7684\u4e3b\u8981\u4e0a\u6e38\u89e6\u53d1\u56e0\u7d20\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u62b5\u6d88\u8fd9\u79cd\u635f\u4f24\uff0c\u73b0\u4ee3\u76ae\u80a4\u75c5\u5b66\u7814\u7a76\u805a\u7126\u4e8e\u5177\u6709\u6781\u5f3a\u6297\u6c27\u5316\u80fd\u529b\u7684\u7eb3\u7c73\u6750\u6599\u3002\u5176\u4e2d\uff0c\u78b360\uff08<a href=\"https:\/\/www.thefullerene.com\/about-fullerene\/what-is-fullerene-c60\/\">C60<\/a>\uff09\u5bcc\u52d2\u70ef\u2014\u2014\u4e00\u79cd\u5177\u6709\u4e8c\u5341\u9762\u4f53\u5bf9\u79f0\u6027\u7684\u4e2d\u7a7a\u7403\u5f62\u7b3c\u72b6\u7ed3\u6784\u2014\u2014\u5df2\u6210\u4e3a\u4e00\u79cd\u5353\u8d8a\u7684\u6d3b\u6027\u6210\u5206\u3002\u5b83\u4f5c\u4e3a\u201c\u81ea\u7531\u57fa\u6d77\u7ef5\u201d\uff0c\u201d <a href=\"https:\/\/www.thefullerene.com\/about-fullerene\/what-is-fullerene-c60\/\">C60<\/a> \u5b83\u4ee5\u50ac\u5316\u6548\u7387\u4e2d\u548c\u81ea\u7531\u57fa\uff0c\u5176\u6027\u80fd\u8fdc\u8d85\u4f20\u7edf\u6297\u6c27\u5316\u5242\u3002\u672c\u6587\u5168\u9762\u7efc\u8ff0\u4e86\u5bcc\u52d2\u70ef\u8c03\u63a7\u9ed1\u8272\u7d20\u751f\u6210\u7684\u5206\u5b50\u673a\u5236\uff0c\u4ee5\u53ca\u4fdd\u62a4\u4eba\u7c7b\u76ae\u80a4\u514d\u53d7\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u57fa\u56e0\u6bd2\u6027\u7684\u4f5c\u7528\u3002.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u76ee\u5f55<\/h2><nav><ul><li><a href=\"#1-the-melanogenesis-pathway-and-oxidative-triggers\">1. \u9ed1\u8272\u7d20\u751f\u6210\u901a\u8def\u4e0e\u6c27\u5316\u89e6\u53d1\u56e0\u7d20<\/a><\/li><li><a href=\"#undefined-1\">2. C60\u5bf9\u9ed1\u8272\u7d20\u5408\u6210\u7684\u5206\u5b50\u6291\u5236\u673a\u5236<\/a><ul><li><a href=\"#undefined-2\">\u4e0a\u6e38ROS\u6dec\u706d<\/a><\/li><li><a href=\"#undefined-3\">\u4e3b\u9ed1\u8272\u7d20\u751f\u6210\u57fa\u56e0\u7684\u4e0b\u8c03<\/a><\/li><\/ul><\/li><li><a href=\"#3-photoprotection-and-prevention-of-uv-induced-genotoxicity\">3. \u5149\u9632\u62a4\u4e0e\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u9057\u4f20\u6bd2\u6027\u7684\u9884\u9632<\/a><ul><li><a href=\"#prevention-of-dna-damage-and-apoptosis\">\u9884\u9632DNA\u635f\u4f24\u4e0e\u7ec6\u80de\u51cb\u4ea1<\/a><\/li><li><a href=\"#inhibition-of-lipid-peroxidation\">\u6291\u5236\u8102\u8d28\u8fc7\u6c27\u5316<\/a><\/li><\/ul><\/li><li><a href=\"#4-cosmetic-synthesis-and-purity-standards\">4. \u5316\u5986\u54c1\u5408\u6210\u4e0e\u7eaf\u5ea6\u6807\u51c6<\/a><\/li><li><a href=\"#faq\">\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/a><ul><li><a href=\"#how-does-c60-fullerene-differ-from-vitamin-c-as-a-skin-brightening-active\">C60\u5bcc\u52d2\u70ef\u4f5c\u4e3a\u76ae\u80a4\u7f8e\u767d\u6d3b\u6027\u6210\u5206\u4e0e\u7ef4\u751f\u7d20C\u6709\u4f55\u4e0d\u540c\uff1f<\/a><\/li><li><a href=\"#can-fullerenes-be-formulated-in-both-water-based-and-oil-based-cosmetics\">\u5bcc\u52d2\u70ef\u80fd\u5426\u540c\u65f6\u5e94\u7528\u4e8e\u6c34\u6027\u5316\u5986\u54c1\u548c\u6cb9\u6027\u5316\u5986\u54c1\u4e2d\uff1f<\/a><\/li><li><a href=\"#does-c60-provide-actual-spf-protection-like-physical-sunscreens\">C60\u662f\u5426\u80fd\u50cf\u7269\u7406\u9632\u6652\u971c\u4e00\u6837\u63d0\u4f9b\u5b9e\u9645\u7684SPF\u9632\u62a4\uff1f<\/a><\/li><li><a href=\"#how-does-c60-prevent-uv-induced-dna-damage-in-skin-cells\">C60\u5982\u4f55\u9884\u9632\u76ae\u80a4\u7ec6\u80de\u4e2d\u7531\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684DNA\u635f\u4f24\uff1f<\/a><\/li><li><a href=\"#are-there-any-side-effects-or-risks-associated-with-topical-c60\">\u5c40\u90e8\u4f7f\u7528C60\u662f\u5426\u5b58\u5728\u4efb\u4f55\u526f\u4f5c\u7528\u6216\u98ce\u9669\uff1f<\/a><\/li><\/ul><\/li><li><a href=\"#references\">\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"1-the-melanogenesis-pathway-and-oxidative-triggers\" class=\"wp-block-heading\">1. \u9ed1\u8272\u7d20\u751f\u6210\u901a\u8def\u4e0e\u6c27\u5316\u89e6\u53d1\u56e0\u7d20<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed1\u8272\u7d20\u751f\u6210\u662f\u4e00\u4e2a\u9ad8\u5ea6\u8c03\u63a7\u7684\u751f\u5316\u9014\u5f84\uff0c\u53d1\u751f\u5728\u79f0\u4e3a\u9ed1\u7d20\u4f53\u7684\u7279\u6b8a\u6eb6\u9176\u4f53\u6837\u7ec6\u80de\u5668\u5185\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5668\u4f4d\u4e8e\u8868\u76ae\u9ed1\u7d20\u7ec6\u80de\u4e2d\u3002\u8be5\u9014\u5f84\u7684\u57fa\u7840\u9650\u901f\u6b65\u9aa4\u7531\u916a\u6c28\u9178\u9176\uff08EC 1.14.18.1\uff09\u63a7\u5236\uff0c\u8fd9\u662f\u4e00\u79cd\u542b\u94dc\u7684\u91d1\u5c5e\u9176\u3002. <a href=\"https:\/\/en.wikipedia.org\/wiki\/Tyrosinase\" data-type=\"link\" data-id=\"https:\/\/en.wikipedia.org\/wiki\/Tyrosinase\" rel=\"nofollow noopener\" target=\"_blank\">\u916a\u6c28\u9178\u9176<\/a> \u534f\u8c03\u4e24\u4e2a\u8fde\u7eed\u4e14\u4e0d\u540c\u7684\u53cd\u5e94\uff1a<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>\u5355\u915a\u9176\u5faa\u73af\uff0c\u5c06L-\u916a\u6c28\u9178\u7f9f\u57fa\u5316\u4e3aL-3,4-\u4e8c\u7f9f\u57fa\u82ef\u4e19\u6c28\u9178\uff08L-DOPA\uff09\u3002.<\/li>\n\n\n\n<li>\u4e8c\u915a\u9176\u5faa\u73af\uff0c\u5c06L-DOPA\u6c27\u5316\u4e3a\u9ad8\u6d3b\u6027\u7684\u90bb\u4f4d\u591a\u5df4\u918c\u3002.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u7f3a\u4e4f\u5def\u57fa\u5316\u5408\u7269\uff08\u5982\u8c37\u80f1\u7518\u80bd\u6216\u534a\u80f1\u6c28\u9178\uff09\u7684\u60c5\u51b5\u4e0b\uff0c\u90bb\u4f4d\u591a\u5df4\u918c\u8fc5\u901f\u53d1\u751f <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.2c00306\" data-type=\"link\" data-id=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.chemrev.2c00306\" rel=\"nofollow noopener\" target=\"_blank\">\u975e\u9176\u4fc3\u73af\u5316<\/a> \u5f62\u6210\u591a\u5df4\u8272\u7d20\u3002\u8be5\u4e2d\u95f4\u4f53\u968f\u540e\u7531\u916a\u6c28\u9178\u9176\u76f8\u5173\u86cb\u767d1\uff08TRP-1\uff09\u548c\u916a\u6c28\u9178\u9176\u76f8\u5173\u86cb\u767d2\uff08TRP-2\uff09\u50ac\u5316\uff0c\u751f\u6210\u4e0d\u6eb6\u6027\u7684\u68d5\u9ed1\u8272\u8272\u7d20\u771f\u9ed1\u8272\u7d20\u3002.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"686\" src=\"https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-1024x686.webp\" alt=\"\" class=\"wp-image-2400\" title=\"\" srcset=\"https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-1024x686.webp 1024w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-720x482.webp 720w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-300x201.webp 300w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-768x515.webp 768w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-1536x1029.webp 1536w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html-18x12.webp 18w, https:\/\/www.thefullerene.com\/wp-content\/uploads\/2026\/05\/42003_2025_8725_fig1_html.webp 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">\u4e0d\u540c\u7c7b\u578b\u7d2b\u5916\u7ebf\u8f90\u5c04\u7a7f\u900f\u7ec6\u80de\u7684\u6df1\u5ea6\uff0c\u5f62\u6210\u4e0d\u540c\u7684\u76ae\u80a4\u5c42\u6b21\uff0c\u4ee5\u53ca\u7531\u8fd9\u79cd\u8f90\u5c04\u5f15\u8d77\u7684\u7ec6\u80de\u529f\u80fd\u7684\u4e3b\u8981\u53d8\u5316<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f16\u7801\u916a\u6c28\u9178\u9176\u3001TRP-1\u548cTRP-2\u7684\u57fa\u56e0\u8f6c\u5f55\u7531\u4e3b\u8c03\u63a7\u56e0\u5b50\u2014\u2014\u5c0f\u773c\u7578\u5f62\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50\uff08MITF\uff09\u534f\u8c03\u3002\u5728\u7d2b\u5916\u7ebf\u7167\u5c04\u4e0b\uff0c\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u91ca\u653e\u03b1-\u9ed1\u7d20\u7ec6\u80de\u523a\u6fc0\u6fc0\u7d20\uff08\u03b1-MSH\uff09\uff0c\u8be5\u6fc0\u7d20\u4e0e\u9ed1\u7d20\u7ec6\u80de\u4e0a\u7684\u9ed1\u76ae\u8d28\u7d20-1\u53d7\u4f53\uff08MC1R\uff09\u7ed3\u5408\uff0c\u89e6\u53d1cAMP\/\u86cb\u767d\u6fc0\u9176A\uff08PKA\uff09\u4fe1\u53f7\u901a\u8def\uff0c\u4ece\u800c\u4e0a\u8c03MITF\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u65f6\uff0c\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684ROS\u4f5c\u4e3a\u6709\u6548\u7684\u7b2c\u4e8c\u4fe1\u4f7f\u3002\u8fd9\u4e9b\u81ea\u7531\u57fa\u6fc0\u6d3bp38\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08MAPK\uff09\u901a\u8def\uff0c\u8be5\u901a\u8def\u76f4\u63a5\u78f7\u9178\u5316\u5e76\u6fc0\u6d3b <a href=\"https:\/\/medlineplus.gov\/download\/genetics\/gene\/mitf.pdf\" data-type=\"link\" data-id=\"https:\/\/medlineplus.gov\/download\/genetics\/gene\/mitf.pdf\" rel=\"nofollow noopener\" target=\"_blank\">MITF<\/a>, \uff0c\u5bfc\u81f4\u916a\u6c28\u9178\u9176\u8868\u8fbe\u6025\u5267\u589e\u52a0\uff0c\u5e76\u5f15\u8d77\u53ef\u89c1\u7684\u8272\u7d20\u6c89\u7740\u8fc7\u5ea6\u3002.<\/p>\n\n\n\n<h2 id=\"undefined-1\" class=\"wp-block-heading\">2. \u9ed1\u8272\u7d20\u5408\u6210\u7684\u5206\u5b50\u6291\u5236\u673a\u5236 <a href=\"https:\/\/www.thefullerene.com\/about-fullerene\/what-is-fullerene-c60\/\">C60<\/a><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bcc\u52d2\u70efC60\u4e3b\u8981\u901a\u8fc7\u5728\u5176\u89e6\u53d1\u9ed1\u8272\u7d20\u751f\u6210\u7684\u8f6c\u5f55\u673a\u5236\u4e4b\u524d\uff0c\u62e6\u622a\u4e0a\u6e38\u6c27\u5316\u4fe1\u53f7\u6765\u63a7\u5236\u8272\u7d20\u6c89\u7740\u8fc7\u5ea6\u3002.<\/p>\n\n\n\n<h3 id=\"undefined-2\" class=\"wp-block-heading\">\u4e0a\u6e38ROS\u6dec\u706d<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u88ab\u914d\u5236\u6210\u6c34\u6eb6\u6027\u3001\u805a\u5408\u7269\u5305\u88f9\u7684\u884d\u751f\u7269\uff08\u901a\u5e38\u7528\u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e\uff08PVP\uff09\u7a33\u5b9a\uff0c\u5e76\u88ab\u79f0\u4e3a\u201c\u81ea\u7531\u57fa\u6d77\u7ef5\u201d\uff09\u65f6\uff0cC60\u5145\u5f53 <a href=\"https:\/\/starwars.fandom.com\/wiki\/Molecular_shielding\" rel=\"nofollow noopener\" target=\"_blank\">\u5206\u5b50\u76fe\u724c<\/a>. \u3002\u5728UVA\u7167\u5c04\u4e0b\uff0c\u9ed1\u7d20\u7ec6\u80de\u5185\u7684\u5bcc\u52d2\u70ef\u8fc5\u901f\u5438\u6536\u5e76\u6dec\u706d\u6d3b\u6027\u7269\u8d28\uff0c\u6d88\u9664\u6c27\u5316\u89e6\u53d1\u4fe1\u53f7\u3002\u5b89\u57f9\u6cd5\u548c\u8367\u5149\u6d4b\u5b9a\u6cd5\u8bc1\u5b9e\uff0c\u8fd9\u79cd\u6301\u4e45\u7684\u81ea\u7531\u57fa\u6e05\u9664\u4f5c\u7528\u963b\u6b62\u4e86p38 MAPK\u7ea7\u8054\u53cd\u5e94\u7684\u6fc0\u6d3b\u3002.<\/p>\n\n\n\n<h3 id=\"undefined-3\" class=\"wp-block-heading\">\u4e3b\u9ed1\u8272\u7d20\u751f\u6210\u57fa\u56e0\u7684\u4e0b\u8c03<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u8fc7\u963b\u65adROS\u4ecb\u5bfc\u7684MITF\u6fc0\u6d3b\uff0cC60\u6291\u5236\u4e86\u6574\u4e2a\u9ed1\u8272\u7d20\u751f\u6210\u591a\u9176\u590d\u5408\u7269\u7684\u4e0b\u6e38\u8868\u8fbe\u3002\u7814\u7a76\u8868\u660e\uff0cC60\u5904\u7406\u663e\u8457\u4e0b\u8c03\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MITF<\/strong> \u57fa\u56e0\u548c\u86cb\u767d\u8d28\u8868\u8fbe\u3002.<\/li>\n\n\n\n<li><strong>\u916a\u6c28\u9178\u9176<\/strong> \u9176\u6d3b\u6027\u548c\u603b\u86cb\u767d\u6c34\u5e73\u3002.<\/li>\n\n\n\n<li><strong>TRP-1\u548cTRP-2<\/strong> \u8f6c\u5f55\uff0c\u963b\u6b62\u9ed1\u7d20\u4f53\u6210\u719f\u3002.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u5916\uff0c\u5bcc\u52d2\u70ef\u6291\u5236UVB\u7167\u5c04\u540e\u91cd\u5efa\u4eba\u8868\u76ae\uff08RhE\uff09\u4e2d\u524d\u5217\u817a\u7d20E2\uff08PGE2\uff09\u7684\u5408\u6210\u3002\u7531\u4e8ePGE2\u4f5c\u4e3a <a href=\"https:\/\/en.wikipedia.org\/wiki\/Paracrine_signaling\" rel=\"nofollow noopener\" target=\"_blank\">\u65c1\u5206\u6ccc\u523a\u6fc0\u56e0\u5b50<\/a> \u589e\u52a0\u916a\u6c28\u9178\u9176\u6d3b\u6027\u5e76\u4fc3\u8fdb\u9ed1\u7d20\u7ec6\u80de\u7684\u6811\u7a81\u5f62\u6210\uff08\u4f7f\u5176\u80fd\u591f\u5c06\u6210\u719f\u7684\u9ed1\u7d20\u4f53\u8f6c\u79fb\u81f3\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\uff09\uff0cC60\u5bf9\u5176\u7684\u4e0b\u8c03\u4f5c\u7528\u6784\u6210\u4e86\u9632\u6b62\u76ae\u80a4\u6652\u9ed1\u548c\u8272\u6591\u5f62\u6210\u7684\u5f3a\u5927\u6b21\u7ea7\u673a\u5236\u3002.<\/p>\n\n\n\n<h2 id=\"3-photoprotection-and-prevention-of-uv-induced-genotoxicity\" class=\"wp-block-heading\">3. \u5149\u9632\u62a4\u4e0e\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u9057\u4f20\u6bd2\u6027\u7684\u9884\u9632<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f20\u7edf\u7684\u7f8e\u767d\u6d3b\u6027\u6210\u5206\u4ec5\u4e13\u6ce8\u4e8e\u9176\u4fc3\u9014\u5f84\uff0c\u800cC60\u5219\u901a\u8fc7\u4fdd\u62a4\u8868\u76ae\u7ec6\u80de\u514d\u53d7\u7269\u7406\u6027\u7d2b\u5916\u7ebf\u635f\u4f24\u548c\u57fa\u56e0\u6bd2\u6027\uff0c\u63d0\u4f9b\u5e7f\u8c31\u9632\u62a4\u3002.<\/p>\n\n\n\n<h3 id=\"prevention-of-dna-damage-and-apoptosis\" class=\"wp-block-heading\">\u9884\u9632DNA\u635f\u4f24\u4e0e\u7ec6\u80de\u51cb\u4ea1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8d85\u9ad8\u7f9f\u57fa\u5316\u5bcc\u52d2\u70ef\u884d\u751f\u7269\uff0c\u6216 <a href=\"https:\/\/www.researchgate.net\/publication\/47366690_Fullerenol_A_new_nanopharmaceutic\" rel=\"nofollow noopener\" target=\"_blank\">\u5bcc\u52d2\u9187<\/a> \uff08\u4f8b\u5982C\u2086\u2080(OH)\u2084\u2084\uff09\uff0c\u5177\u6709\u5353\u8d8a\u7684\u6c34\u6eb6\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\u3002\u5728\u4eba\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\uff08HaCaT\uff09\u4e2d\uff0c\u7528\u5bcc\u52d2\u9187\u9884\u5904\u7406\u53ef\u663e\u8457\u6291\u5236UVB\u5149\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\uff0c\u5bcc\u52d2\u9187\u4e2d\u548c\u653b\u51fb\u7ec6\u80de\u6838\u7684\u7f9f\u57fa\u81ea\u7531\u57fa\uff08\u2022OH\uff09\uff0c\u663e\u8457\u51cf\u5c11\u67d3\u8272\u8d28\u51dd\u805a\uff0c\u5e76\u6291\u5236\u73af\u4e01\u70f7\u5627\u5576\u4e8c\u805a\u4f53\uff08CPD\uff09\u7684\u5f62\u6210\u2014\u2014\u8fd9\u662f\u5bfc\u81f4\u76ae\u80a4\u764c\u53d1\u751f\u7684\u4e3b\u8981\u57fa\u56e0\u7a81\u53d8\u3002.<\/p>\n\n\n\n<h3 id=\"inhibition-of-lipid-peroxidation\" class=\"wp-block-heading\">\u6291\u5236\u8102\u8d28\u8fc7\u6c27\u5316<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ae\u8102\uff0c\u7279\u522b\u662f <a href=\"https:\/\/en.wikipedia.org\/wiki\/Squalene\" rel=\"nofollow noopener\" target=\"_blank\">\u89d2\u9ca8\u70ef<\/a>, \uff0c\u6781\u6613\u53d7\u5230UVB\u8bf1\u5bfc\u7684\u8fc7\u6c27\u5316\u4f5c\u7528\uff0c\u4ea7\u751f\u708e\u75c7\u526f\u4ea7\u7269\uff0c\u635f\u5bb3\u76ae\u80a4\u5c4f\u969c\u5e76\u52a0\u5267\u5bfb\u5e38\u75e4\u75ae\u3002\u4eb2\u8102\u6027C60\uff0c\u5f53\u6eb6\u89e3\u4e8e\u690d\u7269\u6765\u6e90\u7684\u89d2\u9ca8\u70f7\u4e2d\u65f6\uff08\u4f8b\u5982LipoFullerene\uff09\uff0c\u80fd\u8f7b\u677e\u6574\u5408\u5230\u89d2\u8d28\u5c42\u548c\u76ae\u8102\u817a\u7684\u8102\u8d28\u53cc\u5206\u5b50\u5c42\u4e2d\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728UVB\u7167\u5c04\u4e0b\uff0c\u4eb2\u8102\u6027C60\u53ef\u9632\u6b62\u89d2\u9ca8\u70ef\u7684\u6c27\u5316\u964d\u89e3\uff0c\u7ef4\u6301\u819c\u6d41\u52a8\u52a8\u529b\u5b66\uff0c\u51cf\u5c11\u76ae\u80a4\u7ea2\u6591\uff0c\u5e76\u964d\u4f4e\u708e\u75c7\u6027\u75e4\u75ae\u75c5\u53d8\uff0c\u540c\u65f6\u4e0d\u7834\u574f\u5929\u7136\u5c4f\u969c\u529f\u80fd\u3002.<\/p>\n\n\n\n<h2 id=\"4-cosmetic-synthesis-and-purity-standards\" class=\"wp-block-heading\">4. \u5316\u5986\u54c1\u5408\u6210\u4e0e\u7eaf\u5ea6\u6807\u51c6<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">C60\u5728\u5148\u8fdb\u62a4\u80a4\u914d\u65b9\u4e2d\u7684\u529f\u6548\u4e25\u683c\u4f9d\u8d56\u4e8e\u5176\u5206\u5b50\u7eaf\u5ea6\u3002\u4f20\u7edf\u7684\u5bcc\u52d2\u70ef\u5408\u6210\u65b9\u6cd5\u901a\u8fc7 <a href=\"https:\/\/www.thefullerene.com\/what-is-the-arc-discharge-method\/\" data-type=\"link\" data-id=\"https:\/\/www.thefullerene.com\/what-is-the-arc-discharge-method\/\">\u78b3\u5f27\u653e\u7535<\/a> \u901a\u5e38\u4f7f\u7528\u7532\u82ef\u7b49\u6709\u673a\u6eb6\u5242\u8fdb\u884c\u63d0\u53d6\u548c\u5206\u79bb\u3002\u5982\u679c\u8fd9\u4e9b\u75d5\u91cf\u82b3\u9999\u70c3\u6b8b\u7559\u7269\u88ab\u56f0\u5728\u7a7a\u5fc3\u78b3\u7b3c\u5185\uff0c\u5b83\u4eec\u53ef\u80fd\u8bf1\u5bfc\u4e25\u91cd\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u62b5\u6d88\u4efb\u4f55\u751f\u7269\u5b66\u76ca\u5904\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u5b89\u5168\u6027\u95ee\u9898\uff0c\u4f18\u8d28\u62a4\u80a4\u54c1\u539f\u6599\u5728\u4e25\u683c\u7684\u836f\u54c1\u6807\u51c6\u4e0b\u751f\u4ea7\u3002\u884c\u4e1a\u9886\u5bfc\u8005\u5982Carbonsphere\uff0c\u4e0e\u751f\u7269\u6280\u672f\u5148\u9a71Healthyking\u5408\u4f5c\uff0c\u5229\u7528\u5148\u8fdb\u7684 <a href=\"https:\/\/www.thefullerene.com\/what-is-continuous-combustion-fullerene\/\">\u8fde\u7eed\u71c3\u70e7\u6280\u672f<\/a>. \u3002\u8fd9\u79cd\u73af\u4fdd\u3001\u65e0\u6eb6\u5242\u7684\u7eaf\u5316\u8fc7\u7a0b\u6d88\u9664\u4e86\u6240\u6709\u6325\u53d1\u6027\u6709\u673a\u5316\u5408\u7269\uff0c\u751f\u4ea7\u51fa\u8d85\u9ad8\u7eaf\u5ea6\uff0899.95%\uff09\u7684\u5316\u5986\u54c1\u7ea7C60\u6210\u5206\uff0c\u7ecf\u751f\u7269\u5b66\u9a8c\u8bc1\uff0c\u5176\u957f\u671f\u5c40\u90e8\u4f7f\u7528\u5b8c\u5168\u65e0\u6bd2\u3001\u65e0\u523a\u6fc0\u6027\u3002.<\/p>\n\n\n\n<h2 id=\"faq\" class=\"wp-block-heading\">\u5e38\u89c1\u95ee\u9898\u89e3\u7b54<\/h2>\n\n\n\n<h3 id=\"how-does-c60-fullerene-differ-from-vitamin-c-as-a-skin-brightening-active\" class=\"wp-block-heading\">C60\u5bcc\u52d2\u70ef\u4f5c\u4e3a\u76ae\u80a4\u7f8e\u767d\u6d3b\u6027\u6210\u5206\u4e0e\u7ef4\u751f\u7d20C\u6709\u4f55\u4e0d\u540c\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ef4\u751f\u7d20C\uff08L-\u6297\u574f\u8840\u9178\uff09\u4f5c\u4e3a\u4e00\u79cd\u727a\u7272\u6027\u8fd8\u539f\u5242\uff0c\u610f\u5473\u7740\u5b83\u5728\u4e2d\u548c\u81ea\u7531\u57fa\u7684\u8fc7\u7a0b\u4e2d\u4f1a\u88ab\u6d88\u8017\u548c\u6c27\u5316\u3002.<sup><\/sup> \u5b83\u4e5f\u975e\u5e38\u4e0d\u7a33\u5b9a\uff0c\u5728\u66b4\u9732\u4e8e\u5149\u3001\u7a7a\u6c14\u548c\u70ed\u65f6\u4f1a\u53d1\u751f\u964d\u89e3\u3002\u76f8\u53cd\uff0cC60\u662f\u4e00\u79cd\u9ad8\u5ea6\u7a33\u5b9a\u7684\u201c\u81ea\u7531\u57fa\u6d77\u7ef5\u201d\uff0c\u80fd\u4ee5\u50ac\u5316\u65b9\u5f0f\u4e2d\u548c\u591a\u4e2aROS\u5206\u5b50\u800c\u81ea\u8eab\u4e0d\u5206\u89e3\uff0c\u5728\u76ae\u80a4\u5185\u4fdd\u6301\u5176\u5149\u7a33\u5b9a\u6027\u548c\u6548\u529b\u8d85\u8fc724\u5c0f\u65f6\u3002.<\/p>\n\n\n\n<h3 id=\"can-fullerenes-be-formulated-in-both-water-based-and-oil-based-cosmetics\" class=\"wp-block-heading\">\u5bcc\u52d2\u70ef\u80fd\u5426\u540c\u65f6\u5e94\u7528\u4e8e\u6c34\u6027\u5316\u5986\u54c1\u548c\u6cb9\u6027\u5316\u5986\u54c1\u4e2d\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u662f\u7684\u3002\u539f\u59cbC60\u5929\u7136\u758f\u6c34\uff0c\u975e\u5e38\u9002\u5408\u6cb9\u57fa\u914d\u65b9\uff08\u4f8b\u5982\uff0c\u5728\u690d\u7269\u6765\u6e90\u7684\u89d2\u9ca8\u70f7\u4e2d\uff09\uff0c\u4ee5\u9776\u5411\u5bcc\u542b\u76ae\u8102\u7684\u7ed3\u6784\u5e76\u4fdd\u62a4\u7ec6\u80de\u819c\u3002\u5bf9\u4e8e\u7cbe\u534e\u6db2\u548c\u723d\u80a4\u6c34\u7b49\u6c34\u57fa\u5e94\u7528\uff0c\u914d\u65b9\u5e08\u4f7f\u7528\u805a\u5408\u7269\u5305\u88f9\u7684\u590d\u5408\u7269\uff08\u5982PVP\u5305\u88f9\u7684C60\uff09\u6216\u9ad8\u5ea6\u7f9f\u57fa\u5316\u7684\u6c34\u6eb6\u6027\u5bcc\u52d2\u9187\uff08C\u2086\u2080(OH)\u2093\uff09\uff0c\u5b83\u4eec\u6613\u4e8e\u5206\u6563\u5728\u6c34\u76f8\u4e2d\u3002.<\/p>\n\n\n\n<h3 id=\"does-c60-provide-actual-spf-protection-like-physical-sunscreens\" class=\"wp-block-heading\">C60\u662f\u5426\u80fd\u50cf\u7269\u7406\u9632\u6652\u971c\u4e00\u6837\u63d0\u4f9b\u5b9e\u9645\u7684SPF\u9632\u62a4\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\uff0cC60\u4e0d\u80fd\u66ff\u4ee3\u6c27\u5316\u950c\u6216\u4e8c\u6c27\u5316\u949b\u7b49\u65e0\u673a\u7d2b\u5916\u7ebf\u8fc7\u6ee4\u5242\u3002\u867d\u7136C60\u5177\u6709\u5149\u6563\u5c04\u548c\u4e00\u5b9a\u7684\u7d2b\u5916\u7ebf\u5438\u6536\u7279\u6027\uff0c\u4f46\u5176\u4e3b\u8981\u4f5c\u7528\u662f\u751f\u7269\u6027\u5149\u9632\u62a4\u3002\u5b83\u4f5c\u4e3a\u4e8c\u7ea7\u9632\u5fa1\uff0c\u4e2d\u548c\u90a3\u4e9b\u7a7f\u8fc7\u521d\u7ea7\u9632\u6652\u971c\u7684\u7d2b\u5916\u7ebf\u6240\u4ea7\u751f\u7684\u5927\u91cf\u6d3b\u6027\u6c27\uff0c\u4ece\u800c\u9632\u6b62\u7ec6\u80de\u574f\u6b7b\u548cDNA\u635f\u4f24\u3002.<\/p>\n\n\n\n<h3 id=\"how-does-c60-prevent-uv-induced-dna-damage-in-skin-cells\" class=\"wp-block-heading\">C60\u5982\u4f55\u9884\u9632\u76ae\u80a4\u7ec6\u80de\u4e2d\u7531\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684DNA\u635f\u4f24\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">UVA\u548cUVB\u66b4\u9732\u4f1a\u4ea7\u751f\u7ec6\u80de\u5185\u8d85\u6c27\u5316\u7269\u548c\u7f9f\u57fa\u81ea\u7531\u57fa\uff0c\u653b\u51fbDNA\u94fe\u3002\u5bcc\u52d2\u70ef\u8fc5\u901f\u8fdb\u5165\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u5e76\u6e05\u9664\u8fd9\u4e9b\u5c40\u90e8\u81ea\u7531\u57fa\uff0c\u663e\u8457\u6291\u5236\u67d3\u8272\u8d28\u51dd\u805a\u548c\u73af\u4e01\u70f7\u5627\u5576\u4e8c\u805a\u4f53\uff08CPD\uff09\u7684\u5f62\u6210\uff0c\u800cCPD\u662f\u76ae\u80a4\u764c\u7684\u4e3b\u8981\u524d\u4f53\u3002.<\/p>\n\n\n\n<h3 id=\"are-there-any-side-effects-or-risks-associated-with-topical-c60\" class=\"wp-block-heading\">\u5c40\u90e8\u4f7f\u7528C60\u662f\u5426\u5b58\u5728\u4efb\u4f55\u526f\u4f5c\u7528\u6216\u98ce\u9669\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f53\u5185\u548c\u4f53\u5916\u76ae\u80a4\u75c5\u5b66\u5b89\u5168\u6027\u7814\u7a76\u5df2\u8bc1\u660e\uff0c\u9ad8\u7eaf\u5ea6\u3001\u5316\u5986\u54c1\u7ea7C60\uff08\u4f8b\u5982\u7531Carbonsphere\u548cHealthyking\u751f\u4ea7\u7684\u5347\u534e\u3001\u65e0\u6eb6\u5242\u7b49\u7ea7\uff09\u4e0d\u4f1a\u5f15\u8d77\u76ae\u80a4\u523a\u6fc0\u3001\u81f4\u654f\u6216\u57fa\u56e0\u6bd2\u6027\u3002\u4e3b\u8981\u98ce\u9669\u5b58\u5728\u4e8e\u4f4e\u7b49\u7ea7\u7684\u5de5\u4e1a\u7ea7C60\u4e2d\uff0c\u5176\u53ef\u80fd\u542b\u6709\u6b8b\u7559\u7684\u7532\u82ef\u6eb6\u5242\u3002.<sup><\/sup><\/p>\n\n\n\n<h2 id=\"references\" class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Xiao, L., Matsubayashi, K., &amp; Miwa, N. (2007). <em>\u6c34\u6eb6\u6027\u805a\u5408\u7269\u5305\u88f9\u5bcc\u52d2\u70ef\u884d\u751f\u7269\u901a\u8fc7\u4e0b\u8c03\u4eba\u9ed1\u7d20\u7ec6\u80de\u548c\u76ae\u80a4\u7ec4\u7ec7\u4e2d\u916a\u6c28\u9178\u9176\u8868\u8fbe\u5bf9UVA\u8bf1\u5bfc\u9ed1\u8272\u7d20\u751f\u6210\u7684\u6291\u5236\u4f5c\u7528\u3002.<\/em> \u300a\u76ae\u80a4\u75c5\u5b66\u7814\u7a76\u6863\u6848\u300b\uff0c299(5-6)\uff0c245-257\u3002. <a href=\"https:\/\/doi.org\/10.1007\/s00403-007-0740-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1007\/s00403-007-0740-2<\/a> \u201c<\/li>\n\n\n\n<li>Saitoh, Y., Miyanishi, A., Mizuno, H., Kato, S., Aoshima, H., Kokubo, K., &amp; Miwa, N. (2011). <em>\u8d85\u9ad8\u7f9f\u57fa\u5316\u5bcc\u52d2\u70ef\u884d\u751f\u7269\u901a\u8fc7\u51cf\u5c11\u7ec6\u80de\u5185ROS\u751f\u6210\u548cDNA\u635f\u4f24\u4fdd\u62a4\u4eba\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u514d\u53d7\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u7ec6\u80de\u635f\u4f24\u3002.<\/em> \u300a\u5149\u5316\u5b66\u4e0e\u5149\u751f\u7269\u5b66B\u8f91\uff1a\u751f\u7269\u5b66\u300b\uff0c102(1)\uff0c69-76\u3002. <a href=\"https:\/\/doi.org\/10.1016\/j.jphotobiol.2010.09.006\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1016\/j.jphotobiol.2010.09.006<\/a> \u201c<\/li>\n\n\n\n<li>Aoshima, H., Yamana, S., Nakamura, S., &amp; Mashino, T. (2010). <em>\u6c34\u6eb6\u6027\u805a\u5408\u7269\u5305\u88f9\u5bcc\u52d2\u70ef\u4f5c\u4e3a\u5316\u5986\u54c1\u548c\u836f\u7269\u5236\u5242\u4e2d\u6297\u6c27\u5316\u5242\u7684\u5b89\u5168\u6027\u8bc4\u4ef7\u3002.<\/em> \u300a\u6bd2\u7406\u79d1\u5b66\u6742\u5fd7\u300b\uff0c35(3)\uff0c401-409\u3002. <a href=\"https:\/\/doi.org\/10.2131\/jts.35.401\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.2131\/jts.35.401<\/a> \u201c<\/li>\n\n\n\n<li>Inui, S., Aoshima, H., Nishimori, A., &amp; Itami, S. (2011). <em>\u5c40\u90e8\u4f7f\u7528\u5bcc\u52d2\u70ef\u6539\u5584\u5bfb\u5e38\u75e4\u75ae\u3002.<\/em> \u300a\u76ae\u80a4\u75c5\u5b66\u6742\u5fd7\u300b\uff0c38(11)\uff0c1072-1077\u3002. <a href=\"https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01257.x\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1111\/j.1346-8138.2011.01257.x<\/a> \u201c<\/li>\n\n\n\n<li>\u5316\u5986\u54c1\u4e2d\u5bcc\u52d2\u70ef\u5b89\u5168\u6027\u8bc4\u4f30\u6807\u51c6\u5316\u6307\u5357\u3002(2023). \u6b27\u76df\u59d4\u5458\u4f1a\u6d88\u8d39\u8005\u5b89\u5168\u79d1\u5b66\u59d4\u5458\u4f1a\uff08SCCS\uff09\u3002. <a href=\"https:\/\/doi.org\/10.2772\/12171328\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.2772\/12171328<\/a> \u201c<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"<p>The cutaneous interface is constantly exposed to solar ultraviolet radiation (UVR), which is divided into UVB (290\u2013320 nm) and UVA (320\u2013400 nm) wavelengths. While UVB primarily targets the epidermis to cause direct DNA lesions, UVA penetrates deep into the dermis, generating an excess of reactive oxygen species (ROS). This UV-induced oxidative stress represents the primary [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2400,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_gspb_post_css":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-2394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"blocksy_meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/posts\/2394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/comments?post=2394"}],"version-history":[{"count":0,"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/posts\/2394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/media\/2400"}],"wp:attachment":[{"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/media?parent=2394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/categories?post=2394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thefullerene.com\/zh\/wp-json\/wp\/v2\/tags?post=2394"}],"curies":[{"name":"\u5de5\u4f5c\u6587\u4ef6","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}